Original description as Cyprinodon labiosus:
- Humphries, Julian & R.R. Miller. 1981. "A remarkable species flock of pupfishes, genus Cyprinodon, from Yucatán, Mexico". Copeia. v. 1981(n. 1), pp. 52-64 (ffm00180) (abstract)
Conservation: Cyprinodon labiosus is evaluated by the international union for the conservation of nature in the iucn red list of threatened species as (CR) critically endangered (2009).