Original description as Cyprinodon macularius:
- Baird, Spencer F. & C.F. Girard. 1853. "Descriptions of new species of fishes collected by Mr. John H. Clark, on the U. S. and Mexican Boundary Survey, under Lt. Col. Jas. D. Graham". Proceedings of the Academy of Natural Sciences of Philadelphia. 6:387-390 (ffm04562)
- Cyprinodon californiensis Girard, 1859, with type locality at Neighborhood of San Diego, California, U.S.A. Determiner: Lazara, 2001
- Lucania browni Jordan & Richardson, 1907, with type locality at Hot spring, 40 miles south of Calexico, Baja California. Determiner: Lazara, 2001
Conservation: Cyprinodon macularius is not evaluated by the international union for the conservation of nature in the iucn red list of threatened species.